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White Papers and Videos

Automate Your SARS-CoV-2 S1/RBD IgG Ab ELISA and Increase Your Sample Throughput

White Paper

The Freedom EVOlyzer is a dedicated platform that automates all common ELISA steps, including sample distribution, sample predilution, reagent pipetting, incubation, plate washing, optical density reading, and result generation.

This application note compares the results of manual and automated SARS-CoV-2 ELISA workflows and evaluates cross-contamination risk, assay drift, precision, and time to results, finding the automated assay to perform comparably to the manual workflow while increasing throughput.

Quantifying the Impact of Pipette Tip Type Using Dual Dye Ratiometric Technology

White Paper

The type, characteristics, and quality of disposable pipette tips can directly affect the volume transferred to and from an assay, regardless of operator skill or type of pipette employed. This application note from Artel describes the use of a dual-dye photometric technology to correlate the accuracy and repeatability of volume transfers with the disposable pipette tips employed, allowing users to screen and select the appropriate tip types for their liquid handlers, pipettes, and assays.

Pipetting Viscous Solutions – Best Practices

White Paper

This reference poster from Artel describes best practices for pipetting viscous solutions including using positive displacement for methods or reverse mode pipetting.

Artel Lab Reports

White Paper

This ebook from Artel contains a series of publications that provide technical information regarding the use, application, and metrology related to liquid handling instrumentation, including practices for pipette calibration, pipetting technique, and pipette use ergonomics.

Troubleshooting Automation

White Paper

This reference poster from Artel describes how to troubleshoot problems with automated assays, including how to inspect laboratory instruments, consumables, reagents, and other factors that may be causing issues in data.

Sample Collection Methods in COVID-19 Testing, Sequencing, and Research

White Paper

This whitepaper from Zymo Research describes cases in COVID-19 research and testing that demonstrate the use of DNA/RNA Shield, a transport and storage medium that inactivates the virus and prevents sample degradation. Included are cases from Jennifer Doudna’s pop-up testing laboratory at the University of California, Berkeley, convalescent plasma research at the University of New Mexico, and an incident in which samples survived a vehicle fire in Ecuador.

Recommended Safety Measures for Handling COVID-19 Positive Samples

White Paper

The SARS-CoV-2 virus is not only highly infectious, but its RNA genome is notoriously unstable. The primary challenges in COVID-19 testing are safe sample collection and preservation for transport to testing laboratories.

This brief guide from Zymo Research describes recommended measures for safely handling COVID-19 positive samples.

HPV-Based Cervical Cancer Screening: Gaining Insights in Sample Preference and Cost-Effectiveness

White Paper

Cervical cancer can be prevented through vaccination and screening, but it remains the fourth most common cancer type in women, with over 500,000 cases detected in 2018. Most cases of cervical cancer are linked to types of high-risk human papillomavirus (HPV), a common sexually transmitted infection. Regular screening for cervical cancer with pap smears improves incidence and mortality rates, but many women are reluctant to undergo a pap smear due to the invasiveness of cervical sampling, cultural reasons, lack of time, and the need to visit a clinician.

This whitepaper from Novosanis reviews studies examining patient preferences and the cost-effectiveness of self-sampling methods for HPV-based cervical cancer screening, highlighting the potential of Colli-Pee — a self-sampling urine-capturing device that collects the first 20 ml of urine flow.

Colli-Pee - Performance of A Game-Changing Sampling Device for HPV-Based Cervical Cancer Screening

White Paper

Cervical cancer causes over 300,000 deaths per year. The introduction of screening programs to detect pre-cancer lesions has resulted in a 50 percent reduction of premature deaths. However, non-attendance rates are high: on average 40 percent of women living in developed countries and 80 percent in developing countries do not participate in screening due to the invasiveness of cervical sampling, cultural reasons, lack of time, and the need to visit a clinician.

This whitepaper from Novosanis explains the performance of Colli-Pee — a self-sampling urine-capturing device that collects the first 20 ml of urine flow — in HPV-based cervical cancer screening, highlighting current studies and literature in the field and demonstrating the device’s use for non-invasive, self-administered screening.

Responding to a Pandemic

White Paper

ABC Labs, based at the Karolinska Institute campus in Stockholm, Sweden, was founded soon after the start of the pandemic to establish large-scale PCR and ELISA COVID-19 testing. The laboratory analyzes thousands of tests daily in partnership with Sweden’s Public Health Agency and regional and private healthcare providers.

This case study brief from Tecan describes how ABC Labs employed robotic workstations to scale up their PCR and serology testing over the course of the pandemic from hundreds of samples a day to nearly 20,000.

Protecting Data Integrity and Quality Assurance in Times of Crisis: Technologies Essential to SARS-CoV-2 Sequencing

Video

Clinical Reference Laboratory (CRL) is one of the largest privately held clinical testing laboratories in the US. As the COVID pandemic arose last year, the lab sought to develop a patient-friendly sample collection experience based on saliva instead of nasal pharyngeal swabs. But the test needed to be just as accurate and reliable as standard SARS-CoV-2 tests.

In this on-demand eCase study, Heather Fehling and Rob Grbac of CRL review how they quickly developed a PCR-based COVID-19 saliva test and then rapidly scaled from 300 samples per day to 30,000 samples per day. They discuss how they optimized their processes with the help of Artel’s Multichannel Verification System and review lessons learned from the project.

Download the transcript that accompanies this eCase Study here.

Protecting Data Integrity and Quality Assurance in Times of Crisis: Technologies Essential to SARS-CoV-2 Sequencing - A GenomeWeb eCase Study Transcript

White Paper

This transcript is a companion piece for a GenomeWeb eCase Study in which Heather Fehling and Rob Grbac of Clinical Reference Laboratory discussed how their lab quickly developed a PCR-based COVID-19 saliva test and optimized their processes with the help of Artel's MVS technology. The transcript of the presentation has been lightly edited for clarity and length.

Avoid False Positive ELISA Data

White Paper

Complex samples such as serum and plasma contain a wide variety of substances that may interfere with ELISA outcomes, resulting in false positive data.

This application note from Bio-Techne features three examples of how the company’s proprietary blocking reagents help prevent false positive data in its Quantikine ELISAs as well as that of competitors.

Learn about the importance of optimization in assay development and how Bio-Techne’s in-house testing and careful selection of antibodies, proteins, and diluents help ensure your ELISAs will perform with optimum precision, specificity, accuracy, and sensitivity.

4 Fundamentals of Immunoassay Quality

White Paper

Immunoassay kits can be convenient time-saving tools, but not all assays are created equal. This white paper from Bio-Techne provides a detailed review of the core elements that form the foundation of immunoassay quality and their role in helping to deliver robust, reproducible, and reliable results.

The white paper examines each of these component – recovery, linearity, specificity, and consistency – in detail. It also outlines the strict procedures and protocols Bio-Techne applies to make sure each assay delivers superior performance and consistency as part of a stringent quality control program.

Luminex Assay Users Guide

White Paper

While measuring multiple analytes in a single sample offers numerous advantages, achieving optimum immunoassay outcomes requires careful consideration of multiple factors.

The Luminex Assay Users Guide provides a detailed overview of the performance capabilities and wide-ranging benefits of Luminex multiplex immunoassays. A detailed Q&A section provides answers to common questions related to Luminex performance, preparation protocols, and sample types.