Genetic Classification of Acute Lymphoblastic Leukemia (ALL): RNA Sequencing as an Emerging Clinical Diagnostic Tool
Acute lymphoblastic leukemia (ALL) is a highly heterogenous disease characterized by different genetic alterations of critical importance for a correct clinical diagnosis, disease stratification, disease follow-up, and treatment selection.
ALLs are characterized by gene fusions or display a distinct gene expression signature that can
be used for classification purposes. In this context, RNA-sequencing is becoming an increasingly important diagnostic tool as it can detect gene fusions in an unbiased manner and aid the subtype classification based on distinct gene expression signatures.