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White Papers and Videos

Two Industry Leaders on Dealing With the Growing Complexity of Genomic Cancer Data

White Paper

The Clinical Knowledgebase (CKB) powered by The Jackson Laboratory (JAX) is a dynamic, digital resource for interpreting complex cancer genomic profiles in the context of gene variant knowledge and protein impact, therapies, and clinical trials. Illumina has teamed up with JAX in the newly released Connected Insights software, which integrates CKB as a knowledge source.

In this podcast, Mendelspod’s Theral Timpson speaks to Cara Statz from JAX and Erica Schnettler from Illumina about how their combined technologies are helping researchers and oncologists deal with the increasing complexity of cancer genomic data. They discuss oncologists' experience dealing with an overwhelming amount of new scientific data, and both guests give their advice for new labs setting up cancer testing and oncology clinical research.

Constant Performance System Degassing

White Paper

This ebook from IDEX Health & Science discusses the role of in-line vacuum degassing and presents a new method by which vacuum degassing can be controlled such that the efficiency of the degasser can be set to a constant value at any flow rate.

Advanced Spectral Measurement Systems and Semrock Optical Filters

White Paper

The need for increasingly demanding spectral specifications has required new tools capable of corresponding spectral measurements. Key among these specifications are optical blocking levels and spectral edge steepness measured from UV to NIR wavelengths over a wide range of angles.

This white paper summarizes the features of the proprietary spectral measurement tools developed by IDEX Health & Science, including the established Peregrine and the new KolaDeep Spectral Measurement Systems.

Fittings 101: A Practical Guide to Connections and Fittings in the Laboratory

White Paper

This e-book from IDEX Health & Science provides comprehensive guidance on fittings for laboratory instruments, including how to describe a fitting, how to determine where certain styles of fittings are used in a system, the interchangeability of different types of fittings, and the special terminology and skill set needed to work with hyphenated chromatography systems.

Understanding and Testing Fluid Flow for Custom Valve Design

White Paper

There are many factors taken into consideration during the development of a valve design. Prototyping the complex geometries of valve stators can be expensive and time-consuming but simulation tools can help iterate multiple designs quickly and select the most desirable solutions before the first parts are manufactured.

This white paper from IDEX Health & Science discusses the computer simulation and analysis equipment IDEX Health & Science leverages to reduce valve design iterations and risk of unexpected mechanical failures, evaluate valve components to understand the impact of seal wear, and balance cost, delivery, and design for optimized flow path alignment and tolerancing.

Selecting Filters for Fluorescence Multiplexing

White Paper

The steady advances in optical thin film deposition technology over recent decades have enabled the production of high-performance multiband optical filters that address the increasing demand for multicolor fluorescence instrumentation. Though there is now a wide range of available catalog filters designed for a large variety of fluorophores, selecting suitable filters is often a complex process.

This white paper from IDEX Health & Science presents considerations relevant to selecting multiband optical filters when designing a fluorescence imaging system, particularly one with optical multiplexing.

Powering Diagnostics at Scale: Large Custom Projects

White Paper

This e-book from Cytiva describes customer success stories in which Cytiva collaborated with diagnostics developers on large custom projects to provide lyophilized reagents for a point-of-care device, design and build a multiplex lateral-flow assay, provide magnetic beads for a blood screening test, create kits for a cell analysis device, and create a new facility to lyophilize and package reagents for a sequencing platform.

Powering Diagnostics at Scale: Small- to Mid-Size Custom Projects

White Paper

This e-book from Cytiva describes customer success stories in which Cytiva collaborated with diagnostics developers on small- to mid-sized custom projects to scale up a rapid COVID-19 test, customize an early cancer test, improve a food-and-beverage test, assemble a kit for an immunodiagnostic test, and provide quality control for a diagnostic test.

Fast and Reproducible AAV Vector Quantification with Simple Plex Assays on Ella

White Paper

As part of the viral quantification process, researchers rely on various analytical methods to assess critical quality attributes. While traditional plate-based and dot blot assays can be useful, they are often complex, time-consuming, and non-standardized. To meet increased throughput and safety demands, fast and reproducible titration of viral particles is essential.

This application note from Bio-Techne pairs Simple Plex microfluidic cartridge assays on the Ella automated ELISA platform with Progen antibodies to demonstrate utility for accurate and efficient AAV capsid titer determination, showing how the specificity of Progen’s serotype-specific antibodies helps ensure reliable AAV quantification.

Meeting the Challenges of Early Cancer Detection

White Paper

This solution brief from Bio-Techne describes the drawbacks of relying on circulating tumor DNA for non-invasive early cancer detection and how incorporating proteomics can enhance the sensitivity of early detection tests.

The Role of Proteomics in Early Cancer Detection: A Look at Six Core Benefits

White Paper

The advent of multiomic approaches has improved early cancer detection by integrating diverse molecular data to gain a more complete understanding of early disease processes. While advances in genomic testing have led to progress in developing tools for early diagnosis, many current tests lack the sensitivity required to detect cancers early enough to improve long-term survival.

This white paper from Bio-Techne discusses the potential benefits of incorporating proteomics in early cancer detection, including the ability to track expression patterns over time, the potential for practical implementation in the clinic, and the abundance of proteins and protein types in the bloodstream that have biomarker potential.

Join the Pharmacogenomics Revolution

White Paper

This infographic from Thermo Fisher Scientific shows how pharmacogenomic testing can improve care, lower costs, and reduce health disparities across medical fields.

Integrating Pharmacogenomics Into the Standard of Care

White Paper

Pharmacogenomics (PGx) is used to understand how variations in key areas of an individual’s DNA may impact the efficacy of a medication, dosage considerations, and adverse drug reactions (ADRs). Ideally, testing is performed in advance of prescribing medication so that the physician or the pharmacist can streamline medication selection, reduce trial-and-error, and minimize ADRs. Alternatively, it can help explain why a medication is not working or causing an ADR to get the individual back on the best therapeutic path.

This white paper from Thermo Fisher Scientific discusses hurdles to the wider adoption of PGx and how PGx can improve care and reduce wasted time and costs for the healthcare system, patients, insurers, and patients’ employers — highlighting applications in oncology, pain management, and mental health.

Pharmacogenomics Laboratory Spotlight: Introduction to the PGx Program at the Arkansas Children’s Hospital

White Paper

In this white paper from Thermo Fisher Scientific, the pathologist-in-chief and the pharmacogenomics (PGx) pharmacy clinical coordinator at Arkansas Children's Hospital discuss how they utilize PGx testing, their considerations when selecting panels, the impact of PCR technology, the future of PGx testing at the hospital, and advice for other labs.

Lyophilized Beads: Precision and Consistency at Scale

White Paper

The single-dose accuracy of lyophilized beads is helping to increase the availability of diagnostic testing at the point of care by improving speed to result, reducing the cost per test, and eliminating the need for cold-chain logistics.

This application note from Biofortuna describes the lyophilized bead manufacturing process and evidences the accuracy, precision, and yield they can achieve from a typical manufacturing run of between 200,000 and 300,000 beads.