Knowledge of the interactions between B-cells, T-cells, and follicular dendritic cells within germinal centers (GCs) is important for understanding the main determinant of GC B-cell fates. Given the very complex mixture of GC B-cells undergoing several different transitional states, single-cell transcriptional analysis is an effective way to precisely tackle how mutations occurring in GC-derived B-cell lymphomas affect these states and eventually cause cell transformation.
In this webinar, Dr. Wendy Béguelin of Weill Cornell Medicine will discuss how she used the BD Rhapsody single-cell RNA-seq platform and YFP floxed reporter mouse models to study how lymphoma-associated mutations disrupt the immune system by affecting GC B-cell states, explaining the biology of initiation of low-grade follicular lymphoma.
For Research Use Only. Not for use in diagnostic or therapeutic procedures.