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Knowledge of the interactions between B-cells, T-cells, and follicular dendritic cells within germinal centers (GCs) is important for understanding the main determinant of GC B-cell fates. Given the very complex mixture of GC B-cells undergoing several different transitional states, single-cell transcriptional analysis is an effective way to precisely tackle how mutations occurring in GC-derived B-cell lymphomas affect these states and eventually cause cell transformation.