Application of a Novel ISH Approach to Elucidate Splice Variants in Schizophrenia

December 03, 2018

Application of a Novel ISH Approach to Elucidate Splice Variants in Schizophrenia

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This webinar will demonstrate how a research team at the National Institutes of Health evaluated a novel in situ hybridization approach and applied it to study splice variants related to schizophrenia.

The neurotrophic factor neuregulin-1, as well as its neuronal receptor ErbB4, are risk factors for schizophrenia. Distinct ErbB4 isoforms are generated by alternative splicing, and the levels of specific receptor isoforms are altered in postmortem brains of patients.

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