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Scientist, Sequencing Research & Development

New York Genome Center
Job Location
101 Avenue of the Americas
New York, NY 10013
United States
Job Description

The Sequencing Research & Development (R&D) Lab at NYGC conducts cutting-edge research in support of scientific collaboration, focusing on innovative genomic assay and technology development. A Scientist in the Sequencing R&D Lab will contribute to the discovery, development and implementation of novel strategies to solve complex problems at the forefront of genomics research. The ideal candidate has a background in molecular biology, biochemistry or related fields with experience working with primary cells preferred. Experience with imaging technologies and NGS-based assays is a plus.Strong interpersonal and communication skills are required, as this role will work on an interdisciplinary team and actively collaborate across several functional teams to develop and implement innovative new technologies into production. The ability to thrive in a fast-paced and shifting environment is essential.

Key Responsibilities

  • Develop and implement strategies to prepare samples and libraries for next-generation sequencing platforms, including methods that capture single-cell and multi-modal data, liquid biopsy, long and linked reads and spatial data;
  • Develop protocols for cell dissociation and handling of primary cells to maximize viability in support of single-cell methods;
  • Design and perform relevant experiments to evaluate and develop NGS-based assays and technology;
  • Contribute to troubleshooting and improving current laboratory methods;
  • Analyze, interpret and report scientific findings at NYGC-wide meetings and to senior management;
  • Work with internal and external research groups to conduct experiments using cutting-edge techniques;
  • Demonstrate initiative in identifying opportunities for research and collaboration, working independently, actively and creatively to design and execute strategies to address them;
  • Be a source of knowledge for the team and the rest of the center in applying molecular biology tools to solve specific research problems;
  • Maintain significant knowledge of current, relevant scientific literature and communicate key developments to other group members; and,
  • Take an active part in lab meetings, sharing and improving the knowledge of the team and obtaining information relevant to the team’s goals.
  • PhD degree in a biological science with a strong molecular biology or biochemistry focus;
  • Extensive knowledge of and experience with modern molecular biology tools including prior experience working with primary cells preferred;
  • Experience with difficult library preparation methods (Single-Cell RNA-Seq, ATAC-Seq, etc.) preferred;
  • Proven attention to detail with excellent planning and experimental design skills;
  • Ability to work in an independent manner with minimal supervision but having a strong collaborative personality;
  • Excellent communication skills and experience of writing first-author manuscripts for publication – able to present complex data in simple terms;
  • Excellent analytical and organizational skills, including strong time management and prioritization; and,
  • Strong computing skills highly preferred.


  • Job Mastery- Knowledgeable of current role and technical skills, and the impact it has on the Center.
  • Continuous Learning– Strives to expand the depth and breadth of technical and professional skills.
  • Collaborative– Encourages participation from team members and works effectively with all levels.
  • Credible– Works with a high level of integrity.
  • Communicative– Actively listens to others and uses good judgement as to what to communicate to whom; provides feedback.
  • Focused – Utilizes efficient and effective processes.
  • Adaptable– Demonstrate flexibility with changing priorities.
  • Innovative– Develops new insights and pursues improvements.
  • Takes Ownership– Prioritizes tasks, manages time and delivers on commitments. 

FLSA Status – Exempt

This position is eligible for relocation assistance.

About Our Organization

The New York Genome Center (NYGC) is an independent, nonprofit, academic research organization dedicated to advancing genomic research. NYGC scientists and staff are furthering new approaches to diagnosing and treating neurological diseases and cancer through their unique capabilities in whole genome sequencing, RNA sequencing, state-of-the art analytics, and the development of genomic tools. NYGC concentrates specifically on disease-based research in the following areas: neuropsychiatric disease (autism, schizophrenia, bipolar); neurodegenerative disease (ALS, Alzheimer’s, Parkinson’s, Huntington’s), and cancer.

Located in Lower Manhattan, the New York Genome Center was founded by and remains closely affiliated with twelve leading academic medical centers and research universities in the New York region and beyond, engaging in research projects with and for these institutions. Essential to our collaborative work is an outstanding faculty, whose members typically hold a joint appointment at NYGC and a partner university. They support our scientific mission by conducting independent research in areas of mutual interest to us and the wider scientific community.

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.