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Head of Chemistry

Ansa Biotechnologies
Job Location
1198 65th St
Suite 250
Emeryville, CA 94608
United States

Industry competitive compensation and benefits.

Job Description

As Head of Chemistry, you will work closely with Ansa’s enzyme engineering team to develop new nucleoside triphosphates and linkers for Ansa’s enzymatic DNA synthesis technology. You will be responsible for designing synthesis plans for novel nucleoside triphosphates that can be tethered to a protein via a cleavable linker, coordinating synthesis of key intermediates at CROs, performing final synthesis steps in-house, analyzing the stability and purity of linkers and nucleotides, identifying and eliminating trace impurities, and giving feedback to the team to ensure that project deliverables are met.


PhD in Chemistry or Chemical Biology.

Preferred Skills & Experience:

  • 5+ years experience with nucleic acid chemistry/chemical biology

  • Strong analytical chemistry skills for nucleic acids including reverse-phase and ion-exchange HPLC, LC-MS, 1H and 31P NMR

  • Great analytical skills and a logical approach to problem solving

  • Ability to learn new technical areas quickly and thrive in a multidisciplinary environment

  • Strong interpersonal, verbal communication, and presentation skills

  • Experience synthesizing modified nucleoside triphosphates strongly preferred

  • Experience with enzymatic reactions / molecular biology is a plus

  • Bioconjugation experience is a plus

How to Apply

To apply, please send resume and coverletter to [email protected] 

About Our Organization

Ansa Biotechnologies is developing a new way to make DNA that will be faster, cleaner, and more accurate than existing methods. Currently, DNA is manufactured via a chemical method that has remained mostly unchanged for 35 years. Our enzyme-based approach promises to dramatically accelerate innovation in biological research and biotechnology, including therapeutics, diagnostics and biomanufacturing.