We seek an experienced computational biologist / data scientist to lead our Bioinformatics group in our fight to stop cancer.
In this exciting role as a part of the Precision Oncology group embedded within Oncology Research, the Bioinformatics Lead will direct a group of skilled computational biologists / data scientists in applying statistical, modeling, and machine learning approaches to cancer Drug Discovery and Early Development in both Molecular and Immuno-Oncology.
This group works as an integrated part of Research Teams to design high content experiments, to manage data, and to use advanced analytical and computational techniques to identify from back-translational studies disease endotypes and hypothesis about actionable targets therein. Furthermore, this team and the Bioinformatics Lead will collaborate with Early Development Teams to guide the development of therapeutic agents against those targets with data-driven biomarker plans through Proof of Concept (POC).
Summary of Key Responsibilities:
- Develops and executes computational strategies for disease endotyping from back-translational studies both to identify and to rank actionable targets / combinations
- Develops biomarker plans (e.g., selection, PD, efficacy biomarkers) in collaboration with project teams
- Proactively engages with project teams to define crisp scientific questions that can be addressed with appropriately powered experimental designs
- Applies scientific expertise and judgement to initiate, design, direct and execute experiments and/or studies in support of research and/or development projects. Analyzes, interprets and presents results.
- Manages and develops group of one or more computational biologists / data scientists
- Demonstrates continuous growth in depth and breadth of personal scientific knowledge and understanding of strategic goals of group, team and company.
- Works independently, pro-actively, is an impactful contributor and/or leader of project teams and transverse initiatives, and significantly advances R&D goals beyond group.
- Oversees the continued development of computational methods and pipelines needed for current and future I/O assays, including Multiplex ImmunoFluorescence (MiF), WES/WGS, RNA-seq, TCR/BCR sequencing, neoantigen prediction, CITE/REAP-Seq.
- Oversee the creation of a common informatics platform for data processing