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Bioinformatician (large datasets)

Sophia Genetics SA
Job Location
Rue du Centre 172
1025 St-Sulpice
Job Description

We currently have 2 positions open in the bioinformatics and data science department of SOPHiA Genetics in St. Sulpice/Lausanne, Switzerland. The two persons we are looking for will work on "large gene panels", i.e. on enabling NGS analysis of clinical datasets that represent e.g. a clinically-relevant selection of approximately 5,000 human genes or the whole human exome.

Key tasks and projects include:

  • to create, optimise, and maintain analysis pipelines for exome-sized gene panels
  • to do exploratory analyses and leverage data science to assess and improve the analytical performance of our pipelines
  • one of the two positions will focus in particular on the integration of specialised, cutting-edge analyses such as somatic variant analysis, tumor/normal comparisons, CNV detection, TMB analysis, and MSI detection
  • to implement solutions that meet the particular challenges associated with the analysis of very large data sets (e.g. entire Novaseq runs), in particular in terms of run time and resource usage
  • to perform benchmarking

The ideal candidate should demonstrate excellence in the following areas:

  • PhD and/or several years postdoc or industry experience in bioinformatics and NGS data analysis
  • fluency in R and ideally in another language such as Python, C++, or Perl
  • proven track record of working with high performance computing clusters, bioinformatic analysis pipelines, version control systems, and parallel computing
  • solid knowledge of best practices for software development and testing
  • ability to approach complex problems in a systematic fashion and from a software engineering and technical implementation point of view
  • capacity to work in a fast-paced and multidisciplinary environment

Please note that selected candidates will need to perform a bioinformatic assignment and a self-assessment during the recruitment process. 

If you think you fit this position, please send us your CV and a cover letter! We look forward to hearing from you...