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Garvan Institute of Medical Research
Job Location
384 Victoria St
Darlinghurst NSW 2010
Job Description

The Garvan Institute of Medical Research (Garvan) is one of Australia’s leading medical research institutes, with over 600 scientists, students and support staff.  Its mission is to make significant contributions to medical research that will change the directions of science and medicine and have major impacts on human health. Garvan’s research encompasses genomics and epigenetics, cancer, immunology, bone biology, neuroscience, and diabetes and metabolism. These research activities are organised within four themes: Genomics, Cancer, Inflammatory Diseases, and Healthy Aging, and two Centres: the Kinghorn Centre for Clinical Genomics and the Garvan-Weizmann Centre for Cellular Genomics.

The Human Comparative and Prostate Cancer Genomics (HCPCG) Laboratory is focused on understanding the complexities of the human and cancer genome and how genomic variation has shaped human diversity, health, cancer evolution, risk and outcome.

This is a newly funded position, from the Australian National Health and Medical Research Council (NHMRC), to examine genomic alterations contributing to both ethnic disparities and those driving aggressive prostate cancer. The project is prefaced on the hypothesis that somatic (acquired) genomic alterations are fundamental drivers of clinical heterogeneity and treatment response in prostate cancer.  Thus, the project seeks to identify the somatic genomic landscape as potential biomarkers of disease and treatment outcome by using whole-genome sequencing of tumour and matched normal patient samples.

The Opportunity

Reporting to the Head of HCPCG, the Bioinformatics Research Officer will focus on the implementation of high-throughput computational tools to analyse next-generation sequencing (NGS) data to identify somatic variations associated with prostate cancer.

This is a one year full time opportunity in the first instance with the possibility to extend.

Key Responsibilities

  • Perform computational and statistical analyses of whole genome sequencing data
  • Implement existing bioinformatics tools necessary for large-scale population-level genome analysis
  • Manage movement and storage of genomic data related to the project
  • Ensure appropriate written documentation of work
  • Work independently and as part of a team
  • Support writing of manuscripts related to the project
  • Other duties relevant to the role

About You

  • Postgraduate Degree in a relevant field (e.g. bioinformatics, cancer genomics, or comparative genomics) or Bachelors’ Degree with demonstrated experiences in these fields
  • Experience with bioinformatics or computational analyses, particularly for NGS data
  • Familiarity of NGS technologies, particularly of the Illumina platform
  • Experience with installing and implementing existing bioinformatics software
  • Familiarity with the commandline and use of HPC resource 
How to Apply

All applications must include:

  • A cover letter
  • Your resume including at least 2 referees
  • Copies of relevant qualifications / academic transcripts 

Closing Date
The position will remain open until filled. As we will be reviewing applications as they are received, we encourage you to submit yours as soon as possible.