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Scientist, Product Development - Transcriptomics

Organization

Scale Biosciences

Job Location

Menlo Park
Menlo Park, CA 94025
United States

Job Description

Scale Biosciences, Inc. (“ScaleBio”) is an early-stage life sciences technology and tools company developing advanced single-cell analysis solutions based upon the Company's patented split-pool barcoding and combinatorial indexing technology, to enable scalable, easy-to-adopt, extensible, cost-effective single-cell experiments so make single-cell sequencing across a broad range of systems, sample types and applications accessible to the larger research community.

Our founding team are the key inventors of split-pool barcoding and combinatorial indexing methods and share a common mission develop, democratize and make accessible this important technology for the broader research community to support broad range of applications including Epigenomics, Transcriptomics, Proteomics, and Multi-omics. We have a strong Board, Advisors, and Management Team with a collective proven track record in building successful life sciences tools companies and a growing passionate, multi-disciplinary, diverse team of scientists, engineers, bioinformaticians and software developers.

We have a shared mission, patented and demonstrated technology, long term investment commitments and R&D facilities in San Diego and Bay Area, CA. We are seeking people that have a passion for developing technologies and tools that benefit the broader researcher community in the discovery of human biology, have a strong interest in single-cell sequencing as a disruptive and enabling technology and see the potential for our patented split-pool barcoding and combinatorial indexing methods.

We are seeking passionate, driven Scientists for our Transcriptomics Product Development team (scRNA-seq, targeted sequencing and multi-omics). Reporting to our Transcriptomics lead, you will work hands-on to develop single-cell RNA-seq assay products in support of multiple applications across multiple fields of study.

What You'll Do:

•Systematically design, execute, analyze, and interpret controlled experiments to address key product development requirements for single cell genomics assays.

•Use molecular biology techniques, such as PCR/qPCR and single cell NGS library preparation, to test single cell genomics assays for assay reproducibility, assay robustness, and reagent stability.

•Improve assay performance for existing and new assays based on systematic feedback from customers and collaborators, our field scientist team, and our marketing team.

•Collaborate with internal and external parties and routinely present experimental findings to internal and external parties.

•Aid in the development of QC methods for reagents and consumables for analytical, orthogonal, and functional testing.

•Write, implement, and validate SOPs and customer facing documentation.

•Participate in assay verification and validation experiments.

•Participate in the transition of any product changes from the R&D department to manufacturing and production, helping to identify and mitigate risks.

Requirements

About You:

•Advanced degree in molecular biology, biochemistry, genetics, cell biology or related fields.

•0-1+ years’ experience required for PhD Scientists, 3+ years’ experience required for MS degree holders, 5+ years’ experience required for BS degree holders, with relevant industry experience.

•A driven self-starter committed to working in a fast-paced start-up environment.

•Experience with next generation sequencing, genomics and/or proteomics technologies.

•Relevant experience or knowledge of RNAseq, preferably using single-cell sequencing methods and technologies (e.g. SMART-seq, SPLiT-seq, sci-RNA-seq, scifi-RNA-seq, etc).

•Excellent communication skills & track record of collaboration and teamwork.

•Experience using statistical tools, such as JMP to analyze complex data sets, create DOE experiments, and data trending are a plus.

•Knowledge of and/or experience with Bioinformatics is a plus.

If you desire to be part of a diverse and multi-disciplinary team with a shared mission to develop great products for researchers we'd like to meet you. For more information about ScaleBio, please see our website, <a href="http://www.scale.bio">www.scale.bio</a&gt;. ScaleBio offers you a unique opportunity to play an important role in the development, democratization, and commercialization of our advanced single-cell analysis technology. ScaleBio is in its formative stages and desires to foster a great culture built upon shared core values. ScaleBio strives to provide competitive compensation, health and dental benefits, 401K retirement saving plan. ScaleBio is an equal opportunity employer and intends to develop a diverse and multi-disciplinary workplace.