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NEW YORK (GenomeWeb) – A team from the University of Groningen has demonstrated that it is possible to directly detect small molecule metabolites using a sample preparation-free single-molecule nanopore method.

In work supported in part by Oxford Nanopore Technologies, the researchers established an approach for finding and quantifying levels of glucose or an amino acid called asparagine with a cytolysin A (ClyA) nanopore paired with protein sensors that are based on adapted versions of bacterial binding proteins that specifically interact with these molecules.

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