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NEW YORK (GenomeWeb) – Early clinical trial data on Merck KGaA's c-Met inhibitor tepotinib suggests the drug may be efficacious against lung and liver tumors driven by alterations in the MET oncogene.

The development program for the drug in a molecularly defined non-small cell lung cancer subpopulation includes a companion diagnostic strategy involving tests that can gauge MET exon-14-skipping mutations in tumor tissue and blood.

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