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ClearLight Licenses Microscopy, RNA Interrogation Technologies from Stanford

NEW YORK (GenomeWeb) – ClearLight Diagnostics announced today that it has taken an exclusive, worldwide license to novel microscopy and RNA interrogation technology from Stanford University.

According to ClearLight, the microscopy technology — called spherical-aberration-assisted extended depth-of-field, or SPED — combines the large volumetric field of view of an extended depth of field with the optical sectioning of light sheet microscopy, eliminating the need to physically scan the detection objective for volumetric imaging while maintaining spatial resolution.

The RNA interrogation technology, the company said, enables measurement of activity-dependent transcriptional signatures, cell-identity markers, and diverse non-coding RNAs in rodent and human tissue volumes. It was developed at Stanford for multiplexed, volumetric visualization of both long and short RNAs.

Specific terms of the licensing deal were not disclosed.

"We are excited to add these important technologies to our portfolio related to the three-dimensional interrogation and imaging of tissue samples," ClearLight CEO Sarah McCurdy said in a statement. "We continue to develop a set of valuable tools and capabilities to support our product development of the Clarity process" for creating transparent tissue-gel composites.